TOP PKRRATING SECRETS

3B). R526 in the loop among αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the main chain carbonyl of R413. The tip from the activation phase is stabilized by a hydrogen bond involving Y454 and E480 from αfile. In the FTF